Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | PTGIR | P43119 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280312 | 0.75 | EHMT2 (0.47) | HPGDMAPTHTTALDH1A1 | |
| SCHEMBL2180342 | 0.71 | — | — | |
| SCHEMBL9479768 | 0.71 | HSD17B10 (0.48) | SMN1; SMN2MAPTHSD17B10HTTALDH1A1 | |
| SCHEMBL4448073 | 0.70 | HPGD (0.42) | HPGDSMN1; SMN2MAPTMGLLHSD17B10 | |
| SCHEMBL237661 | 0.67 | HPGD (0.38) | HPGDSMN1; SMN2MAPTMGLLHSD17B10 | |
| SCHEMBL19349014 | 0.67 | — | — | |
| Diphenylsulfane SCHEMBL11466727 | 0.66 | HPGD (0.53) | HPGDSMN1; SMN2MAPTMGLLHSD17B10 | |
| Diphenylsulfane SCHEMBL28332331 | 0.65 | HPGD (0.60) | HPGDSMN1; SMN2MAPTMGLLHSD17B10 | |
| Diphenylsulfane SCHEMBL452 | 0.65 | HPGD (0.60) | HPGDSMN1; SMN2MAPTMGLLHSD17B10 | |
| Diphenylsulfane SCHEMBL27611905 | 0.65 | HPGD (0.60) | HPGDSMN1; SMN2MAPTMGLLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | claimed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | claimed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |