⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2634020 | 0.80 | — | — | |
| SCHEMBL19349014 | 0.76 | — | — | |
| SCHEMBL8809074 | 0.71 | HPGD (0.33) | — | |
| SCHEMBL2180536 | 0.71 | KDM4E (0.30) | — | |
| SCHEMBL11032057 | 0.69 | GPR84 (0.39) | — | |
| SCHEMBL19642331 | 0.67 | — | — | |
| SCHEMBL9479768 | 0.67 | HSD17B10 (0.48) | — | |
| SCHEMBL4280312 | 0.67 | EHMT2 (0.47) | — | |
| SCHEMBL53381 | 0.67 | — | — | |
| SCHEMBL558238 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128373-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2014-05-08 | — | — | US | claimed |
| CN-103517710-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2014-01-15 | — | — | CN | claimed |
| EP-2672967-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2013-12-18 | — | — | EP | claimed |
| WO-2012109075-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2012-08-16 | — | — | WO | claimed |
| US-4895846-A | CARDIOVASCULAR DISORDERS | BRISTOL-MYERS COMPANY (US) | 1990-01-23 | — | — | US | claimed |
| US-4755512-A | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities | BRISTOL-MYERS COMPANY (US) | 1988-07-05 | — | — | US | claimed |
| EP-0201558-A4 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES. | BRISTOL MYERS CO (US) | 1988-04-13 | — | — | EP | claimed |
| EP-0201558-A1 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES | Bristol-Myers Squibb Company (US) | 1986-11-20 | — | — | EP | claimed |
| WO-1986002640-A1 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES | BRISTOL-MYERS COMPANY (US) | 1986-05-09 | — | — | WO | claimed |
| US-4225706-A | Polychalcogen ester of cephem compound, process for preparing the same and method for removing the protective group of the same | MEIJI SEIKA KAISHA LTD. (JP) | 1980-09-30 | — | — | US | claimed |
| US-20230277534-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230026651-A1 | AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS | CYTOKINETICS, INC. | 2023-01-26 | — | — | US | disclosed |
| EP-4023640-A1 | PHENYLIMIDAZOLE COMPOUND | Otsuka Pharmaceutical Factory, Inc. (JP) | 2022-07-06 | — | — | EP | disclosed |
| US-11369565-B2 | Amino-pyrimidine skeletal muscle modulators | CYTOKINETICS, INC. (US) | 2022-06-28 | — | — | US | disclosed |
| US-11337976-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2022-05-24 | — | — | US | disclosed |
| EP-0201558-A4 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES. | BRISTOL MYERS CO (US) | 1988-04-13 | — | — | EP | disclosed |
| EP-0253468-A2 | Six-membered heterocyclic derivatives of N'substituted-N,N'-diacylhydrazines | ROHM AND HAAS COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |
| EP-0201558-A1 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES | Bristol-Myers Squibb Company (US) | 1986-11-20 | — | — | EP | disclosed |
| WO-1986002640-A1 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES | BRISTOL-MYERS COMPANY (US) | 1986-05-09 | — | — | WO | disclosed |
| US-4225706-A | Polychalcogen ester of cephem compound, process for preparing the same and method for removing the protective group of the same | MEIJI SEIKA KAISHA LTD. (JP) | 1980-09-30 | — | — | US | disclosed |