Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 13/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809019 | 0.93 | LTB4R2 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL8486326 | 0.91 | ALDH1A1 (0.49) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL8807794 | 0.91 | LTB4R2 (0.47) | LTB4R2PDE7APDE7BAGTR1 | |
| SCHEMBL8807879 | 0.89 | LTB4R2 (0.39) | LTB4R2PDE7APDE7BAGTR1LPAR1 | |
| SCHEMBL8807800 | 0.88 | LTB4R2 (0.50) | LTB4R2PDE7APDE7BAGTR1 | |
| SCHEMBL8488217 | 0.87 | LTB4R2 (0.50) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL8807632 | 0.85 | LTB4R2 (0.55) | LTB4R2AGTR1 | |
| SCHEMBL8807157 | 0.84 | LTB4R2 (0.39) | LTB4R2PDE7APDE7BLPAR1 | |
| SCHEMBL8487982 | 0.84 | LTB4R2 (0.44) | LTB4R2PDE7APDE7BAGTR1 | |
| SCHEMBL8482879 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |