Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811739 | 0.92 | SMN1; SMN2 (0.44) | KMT2AHPGDALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8591251 | 0.91 | HRH3 (0.39) | MEN1KMT2ACYP2C19ASAH1HPGD | |
| SCHEMBL8443653 | 0.88 | KMT2A (0.46) | MEN1KMT2AASAH1ALDH1A1TDP1 | |
| SCHEMBL8592460 | 0.87 | ASAH1 (0.37) | MEN1KMT2AASAH1ALDH1A1NAMPT | |
| SCHEMBL8595503 | 0.85 | POLB (0.39) | ASAH1ALDH1A1NAMPTPLA2G7TDP1 | |
| SCHEMBL8439456 | 0.84 | KDM4E (0.40) | MEN1KMT2AALDH1A1NAMPTPLA2G7 | |
| SCHEMBL8108487 | 0.84 | TSHR (0.43) | MEN1KMT2AASAH1ALDH1A1NAMPT | |
| SCHEMBL8443006 | 0.83 | POLB (0.41) | CYP2C19ALDH1A1TDP1POLBKDM4E | |
| SCHEMBL8441254 | 0.82 | MEN1 (0.39) | MEN1KMT2AASAH1ALDH1A1NAMPT | |
| SCHEMBL8594638 | 0.82 | PLA2G7 (0.41) | MEN1KMT2ACYP2D6CYP2C19ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |