Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21034524 | 0.82 | AAK1 (0.51) | AAK1IDO1KMT2ACACNA1HCACNA1G | |
| SCHEMBL17516021 | 0.82 | AAK1 (0.51) | AAK1IDO1CACNA1HCACNA1GLMNA | |
| SCHEMBL21034692 | 0.82 | IDO1 (0.54) | AAK1IDO1TDP1CACNA1HCACNA1G | |
| SCHEMBL21035054 | 0.82 | AAK1 (0.48) | AAK1KDM4EIDO1CACNA1HCACNA1G | |
| SCHEMBL21034172 | 0.81 | IDO1 (0.57) | AAK1IDO1CACNA1HCACNA1GLMNA | |
| SCHEMBL21035073 | 0.79 | AAK1 (0.48) | AAK1KDM4EIDO1KMT2ACACNA1H | |
| SCHEMBL22787600 | 0.79 | AAK1 (0.48) | AAK1IDO1PKMCACNA1HCACNA1G | |
| SCHEMBL21035092 | 0.79 | IDO1 (0.57) | AAK1IDO1CACNA1HCACNA1GLMNA | |
| SCHEMBL6759257 | 0.78 | IDO1 (0.68) | AAK1IDO1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL17493802 | 0.78 | AAK1 (0.79) | AAK1IDO1CACNA1HCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775134-A4 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMA CORP (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0775134-A1 | Imidazolin-2-ylaminobenzimidazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004270-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-02-15 | — | — | WO | disclosed |