Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808377 | 0.90 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8809649 | 0.89 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8809583 | 0.88 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8808107 | 0.87 | MAPT (0.39) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8810137 | 0.87 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8807960 | 0.87 | MAPT (0.43) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8809365 | 0.82 | F10 (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8807360 | 0.81 | ABCB1 (0.39) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8807291 | 0.81 | ABCG2 (0.42) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8809362 | 0.81 | SMN1; SMN2 (0.43) | MAPTMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |