Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 8/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.48 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | RXRB | P28702 | 4/20 | 0.47 |
| ▸ | RXRG | P48443 | 3/20 | 0.47 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668411 | 0.81 | CYP26B1 (0.52) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL6909472 | 0.79 | CYP26B1 (0.50) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL7142134 | 0.78 | CYP26B1 (0.49) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL4365965 | 0.77 | CYP26B1 (0.55) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL7143302 | 0.76 | CYP26A1 (0.48) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL7144931 | 0.76 | CYP26B1 (0.58) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL9586582 | 0.76 | CYP26B1 (0.70) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL2897524 | 0.75 | CYP26B1 (0.53) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL8811030 | 0.75 | CYP26B1 (0.68) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL16998630 | 0.74 | CYP26B1 (0.51) | CYP26B1CYP26A1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638071-B1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) | EISAI CO LTD (JP) | 1997-04-09 | — | — | EP | disclosed |
| US-5612356-A | RETINOID ANTAGONISTS | EISAI CO., LTD. (JP) | 1997-03-18 | — | — | US | disclosed |
| EP-0638071-A1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR). | EISAI CO LTD (JP) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994014777-A1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) | EISAI CO., LTD. (JP) | 1994-07-07 | — | — | WO | disclosed |