SCHEMBL8809968

SCHEMBL8809968

O=C(O)COc1cccc2c1CCC(CCn1cnc(-c3ccccc3)c1-c1ccccc1)C2

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 20/20 0.59
PTGDR Q13258 8/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8412775 0.91 PTGIR (0.49) PTGIRPTGDR
SCHEMBL8412019 0.91 PTGIR (0.65) PTGIRPTGDR
SCHEMBL8810596 0.88 PTGIR (0.46) PTGIRPTGDR
SCHEMBL8412776 0.87 PTGIR (0.45) PTGIRPTGDR
SCHEMBL8412769 0.80 PTGIR (0.59) PTGIRPTGDR
SCHEMBL8412021 0.79 PTGIR (0.51) PTGIRPTGDR
SCHEMBL8414275 0.79 PTGIR (0.54) PTGIRPTGDR
SCHEMBL8414372 0.78 PTGIR (0.56) PTGIRPTGDR
SCHEMBL8411304 0.77 PTGIR (0.53) PTGIRPTGDR
SCHEMBL7778598 0.77 PTGIR (0.69) PTGIRPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0548949-B1 Fused benzeneoxyacetic acid derivatives ONO PHARMACEUTICAL CO (JP) 1997-09-17 EP claimed
EP-0548949-A2 Fused benzeneoxyacetic acid derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1993-06-30 EP claimed
EP-0548949-B1 Fused benzeneoxyacetic acid derivatives ONO PHARMACEUTICAL CO (JP) 1997-09-17 EP disclosed
US-5589496-A Fused benzeneoxyacetic acid derivatives which have PGI2 receptor agonist activity ONO PHARMACEUTICAL CO., LTD. (JP) 1996-12-31 US disclosed
US-5389666-A Administering for treatment and prevention of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer or hypertension ONO PHARMACEUTICAL CO., LTD. (JP) 1995-02-14 US disclosed
EP-0548949-A2 Fused benzeneoxyacetic acid derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1993-06-30 EP disclosed