Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880933 | 0.89 | KCNH2 (0.49) | NR1I2LMNASMN1; SMN2L3MBTL1KCNH2 | |
| SCHEMBL13520521 | 0.88 | NR1I2 (0.39) | NR1I2LMNAPRKCAMMP12KCNH2 | |
| SCHEMBL10186659 | 0.82 | NR1I2 (0.42) | NR1I2LMNASMN1; SMN2PRKCAMMP12 | |
| SCHEMBL10185755 | 0.82 | PRKCA (0.44) | NR1I2PRKCAMMP12KCNH2CYP3A4 | |
| SCHEMBL881073 | 0.81 | NR1I2 (0.43) | NR1I2LMNAPRKCAMMP12KCNH2 | |
| SCHEMBL841461 | 0.81 | NR1I2 (0.49) | NR1I2L3MBTL1PRKCAMMP12KCNH2 | |
| SCHEMBL881076 | 0.81 | PRKCA (0.45) | NR1I2PRKCAMMP12KCNH2CYP3A4 | |
| SCHEMBL880962 | 0.81 | NR1I2 (0.46) | NR1I2LMNASMN1; SMN2PRKCAMMP12 | |
| SCHEMBL13936872 | 0.80 | NR1I2 (0.61) | NR1I2L3MBTL1PRKCAMMP12KCNH2 | |
| SCHEMBL881001 | 0.79 | NR1I2 (0.48) | NR1I2L3MBTL1PRKCAMMP12KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178878-B1 | TETRACYCLIC COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2009023487-A1 | TETRACYCLIC COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-02-19 | — | — | WO | disclosed |