Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Crotonic Acid SCHEMBL7250369 | 1.00 | HCAR2 (0.44) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL9514096 | 0.92 | HCAR2 (0.54) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL27353762 | 0.92 | HCAR2 (0.54) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL16504 | 0.89 | HCAR2 (0.40) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL16503 | 0.89 | HCAR2 (0.40) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL25405174 | 0.89 | HCAR2 (0.40) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL16505 | 0.89 | HCAR2 (0.40) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL25405178 | 0.89 | HCAR2 (0.40) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL21955999 | 0.86 | HCAR2 (0.45) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL832203 | 0.86 | HCAR2 (0.45) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997028165-A1 | DERIVATIVES OF CAMPTOTHECIN FOR USE IN TREATING CANCER | THE STEHLIN FOUNDATION FOR CANCER RESEARCH (US) | 1997-08-07 | — | — | WO | disclosed |