Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 16/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485968 | 0.92 | LTB4R2 (0.57) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8483211 | 0.91 | LTB4R2 (0.53) | LTB4R2AGTR1PDE7APDE7B | |
| SCHEMBL8814207 | 0.90 | LTB4R2 (0.66) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8813917 | 0.89 | LTB4R2 (0.62) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8811767 | 0.89 | ALDH1A1 (0.53) | LTB4R2AGTR1ABCB11GP6PPARG | |
| SCHEMBL8814779 | 0.88 | LTB4R2 (0.52) | LTB4R2AGTR1ABCB11GP6PDE7A | |
| SCHEMBL8811543 | 0.87 | LTB4R2 (0.44) | LTB4R2AGTR1ABCB11GP6PPARG | |
| SCHEMBL8487982 | 0.86 | LTB4R2 (0.44) | LTB4R2AGTR1ABCB11GP6PPARG | |
| SCHEMBL8812722 | 0.85 | LTB4R2 (0.45) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8812787 | 0.85 | LTB4R2 (0.47) | LTB4R2AGTR1ABCB11GP6PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |