Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | KIF5B | P33176 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812643 | 0.89 | ALK (0.43) | ALKEGFRRAF1BRAFERBB2 | |
| SCHEMBL8492361 | 0.84 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL8810743 | 0.84 | KDR (0.58) | EGFRRAF1ERBB2RETKIF5B | |
| Hydrochloric Acid SCHEMBL8810248 | 0.83 | KDR (0.57) | EGFRRAF1ERBB2RETKIF5B | |
| SCHEMBL8490631 | 0.82 | EGFR (0.55) | EGFRERBB2 | |
| SCHEMBL8308341 | 0.76 | IGF1R (0.50) | ALKEGFRRAF1BRAF | |
| Hydrochloric Acid SCHEMBL8811457 | 0.74 | HDAC3 (0.43) | EGFRERBB2MAPT | |
| SCHEMBL8811481 | 0.73 | HDAC3 (0.46) | EGFRERBB2MAPT | |
| SCHEMBL641359 | 0.73 | EGFR (0.75) | EGFRRAF1BRAFERBB2KDR | |
| SCHEMBL8810511 | 0.72 | HDAC3 (0.45) | EGFRERBB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |