Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308906 | 0.89 | EGFR (0.46) | EGFRALKRIPK2RAF1BRAF | |
| SCHEMBL7245075 | 0.84 | EGFR (0.55) | IGF1RMAP2K1EGFR | |
| Hydrochloric Acid SCHEMBL8310540 | 0.84 | EGFR (0.50) | IGF1RMAP2K1EGFR | |
| SCHEMBL8309667 | 0.84 | IGF1R (0.67) | IGF1RMAP2K1EGFR | |
| Hydrochloric Acid SCHEMBL8304910 | 0.83 | IGF1R (0.66) | IGF1RMAP2K1EGFR | |
| SCHEMBL7232289 | 0.82 | EGFR (0.56) | EGFR | |
| SCHEMBL8615048 | 0.79 | IGF1R (0.50) | IGF1RMAP2K1 | |
| SCHEMBL3808055 | 0.78 | EGFR (0.47) | IGF1RMAP2K1EGFR | |
| SCHEMBL5568727 | 0.77 | EGFR (0.49) | IGF1RMAP2K1EGFR | |
| SCHEMBL8811673 | 0.76 | ALK (0.43) | EGFRALKRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |