Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 9/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813157 | 1.00 | GSK3B (0.51) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8814226 | 0.93 | GSK3B (0.51) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8814220 | 0.93 | GSK3B (0.51) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8813170 | 0.89 | CSNK2A2 (0.44) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8687046 | 0.89 | PARP1 (0.56) | PARP1GSK3APIM1AKR1B1PIM2 | |
| SCHEMBL8685487 | 0.89 | PARP1 (0.56) | PARP1GSK3APIM1AKR1B1PIM2 | |
| SCHEMBL8685971 | 0.86 | PARP1 (0.58) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8809361 | 0.86 | PARP1 (0.58) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8808793 | 0.86 | PARP1 (0.60) | GSK3BPARP1GSK3APIM1AKR1B1 | |
| SCHEMBL8691075 | 0.86 | PARP1 (0.60) | GSK3BPARP1GSK3APIM1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |