Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21342879 | 0.95 | TMPRSS2 (0.41) | TMPRSS2HPRT1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL22342703 | 0.95 | TMPRSS2 (0.41) | TMPRSS2HPRT1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL30001635 | 0.95 | TMPRSS2 (0.41) | TMPRSS2HPRT1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL17719236 | 0.95 | TMPRSS2 (0.41) | TMPRSS2HPRT1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL20882143 | 0.91 | TMPRSS2 (0.36) | TMPRSS2CYP3A4CYP2C9RIPK1 | |
| SCHEMBL881594 | 0.91 | TMPRSS2 (0.35) | TMPRSS2CYP3A4CYP2C9RIPK1 | |
| SCHEMBL882332 | 0.91 | TMPRSS2 (0.35) | TMPRSS2CYP3A4CYP2C9RIPK1 | |
| SCHEMBL24119262 | 0.90 | TMPRSS2 (0.36) | TMPRSS2CYP3A4CYP2C9RIPK1 | |
| SCHEMBL881592 | 0.90 | TMPRSS2 (0.36) | TMPRSS2CYP3A4CYP2C9RIPK1 | |
| SCHEMBL20882193 | 0.90 | HPRT1 (0.37) | HPRT1ALDH1A1CYP3A4CYP2C9RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150608-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | Gilead Sciences, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2012039787-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012039791-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |