SCHEMBL8815310

SCHEMBL8815310

N=C(N)c1ccc2oc(C=Cc3cc4cc(C(=N)N)ccc4o3)cc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PRMT1 Q99873 10/20 0.88
▸ F2 P00734 2/20 0.61
▸ F10 P00742 2/20 0.61
▸ TPSAB1 Q15661 1/20 0.49
▸ TPSD1 Q9BZJ3 1/20 0.49
▸ TPSG1 Q9NRR2 1/20 0.49
▸ PLG P00747 1/20 0.47
▸ PLAU P00749 1/20 0.47
▸ PLAT P00750 1/20 0.47
▸ PRSS1 P07477 1/20 0.47
▸ APP P05067 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979972 1.00 PRMT1 (0.88) PRMT1F2F10TPSAB1TPSD1
SCHEMBL17084488 1.00 PRMT1 (0.88) PRMT1F2F10TPSAB1TPSD1
SCHEMBL12412056 0.94 PRMT1 (1.00) PRMT1F2F10TPSAB1TPSD1
SCHEMBL8229718 0.93 PRMT1 (0.89) PRMT1F2F10TPSAB1TPSD1
SCHEMBL20184755 0.92 PRMT1 (1.00) PRMT1F2F10PLGPLAU
SCHEMBL8229699 0.92 PRMT1 (0.86) PRMT1F2F10TPSAB1TPSD1
SCHEMBL20184763 0.87 PRMT1 (1.00) PRMT1F2F10PLGPLAU
SCHEMBL20184756 0.86 PRMT1 (1.00) PRMT1F2F10PLGPLAU
SCHEMBL8235618 0.85 PRMT1 (0.84) PRMT1F2F10TPSAB1TPSD1
SCHEMBL8229704 0.85 PRMT1 (1.00) PRMT1F2F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996041185-A9 METHODS AND COMPOSITIONS FOR BINDING ENDOTOXINS — 1997-05-15 — — WO claimed
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