SCHEMBL8815519

SCHEMBL8815519

C[C@@H]1OC1(Cn1cncn1)c1ccc(Cl)cc1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 15/20 0.61
THRB P10828 1/20 0.61
CYP2C9 P11712 2/20 0.56
KDM4E B2RXH2 2/20 0.49
LMNA P02545 2/20 0.47
FYN P06241 2/20 0.47
CYP51A1 Q16850 2/20 0.47
NR1I2 O75469 1/20 0.47
PGR P06401 1/20 0.47
HSP90AA1 P07900 1/20 0.47
CHRM2 P08172 1/20 0.47
CHRM4 P08173 1/20 0.47
CHRM5 P08912 1/20 0.47
ADRA2A P08913 1/20 0.47
CHRM1 P11229 1/20 0.47
TSHR P16473 1/20 0.47
ADRA2B P18089 1/20 0.47
ADRA2C P18825 1/20 0.47
CHRM3 P20309 1/20 0.47
DRD1 P21728 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8815515 1.00 CYP3A4 (0.61) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL9302602 0.86 CYP3A4 (0.55) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL9302608 0.86 CYP3A4 (0.55) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL9201672 0.86 CYP3A4 (0.62) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL9201668 0.86 CYP3A4 (0.62) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL9004933 0.85 CYP3A4 (0.44) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL11543229 0.84 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL11550237 0.84 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL11542937 0.84 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL11542933 0.84 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751943-A1 TRIAZOLE COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 1997-01-08 EP disclosed
WO-1995025107-A1 TRIAZOLE COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 1995-09-21 WO disclosed
EP-0332387-B1 Triazole derivatives, their preparation and their use as fungicides SANKYO CO (JP) 1993-11-24 EP disclosed