Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 19/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 19/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 19/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 12/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025916 | 0.91 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL8806547 | 0.85 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7027488 | 0.82 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7034981 | 0.79 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7025901 | 0.79 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7028942 | 0.77 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7087483 | 0.77 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL8807723 | 0.75 | KDM4E (0.31) | KDM4E | |
| SCHEMBL8806757 | 0.75 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL8807389 | 0.74 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775134-A4 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMA CORP (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0775134-A1 | Imidazolin-2-ylaminobenzimidazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004270-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-02-15 | — | — | WO | disclosed |