Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norethindrone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 7/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 5/20 | 0.81 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.81 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.81 |
| ▸ | AR | P10275 | 4/20 | 0.81 |
| ▸ | MEN1 | O00255 | 4/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.81 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 7/20 | 0.59 |
| ▸ | ESR1 | P03372 | 3/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11696763 | 0.97 | CYP3A4 (0.74) | CYP3A4PGRABCB11NR3C1MAPT | |
| SCHEMBL8853780 | 0.97 | CYP3A4 (0.74) | CYP3A4PGRABCB11NR3C1MAPT | |
| SCHEMBL372672 | 0.97 | CYP3A4 (0.74) | CYP3A4PGRABCB11NR3C1MAPT | |
| SCHEMBL11694460 | 0.97 | CYP3A4 (0.74) | CYP3A4PGRABCB11NR3C1MAPT | |
| SCHEMBL354296 | 0.97 | CYP3A4 (0.74) | CYP3A4PGRABCB11NR3C1MAPT | |
| SCHEMBL31432443 | 0.97 | CYP3A4 (0.74) | CYP3A4PGRABCB11NR3C1MAPT | |
| SCHEMBL8853802 | 0.90 | CYP3A4 (0.79) | CYP3A4PGRABCB11NR3C1MAPT | |
| Norethindrone Acetate SCHEMBL11321479 | 0.90 | CYP3A4 (1.00) | CYP3A4PGRABCB11NR3C1MAPT | |
| Norethindrone Acetate SCHEMBL1232662 | 0.90 | CYP3A4 (1.00) | CYP3A4PGRABCB11NR3C1MAPT | |
| Norethindrone Acetate SCHEMBL14577826 | 0.90 | CYP3A4 (1.00) | CYP3A4PGRABCB11NR3C1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997005182-A1 | ANTI-MICROBIAL COATING COMPOSITIONS | ZENECA LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |