Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 5/20 | 0.74 |
| ▸ | PGR | P06401 | 5/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.74 |
| ▸ | AR | P10275 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.74 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | ESR1 | P03372 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | SHBG | P04278 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432443 | 1.00 | CYP3A4 (0.74) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL11696763 | 1.00 | CYP3A4 (0.74) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL8853780 | 1.00 | CYP3A4 (0.74) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL11694460 | 1.00 | CYP3A4 (0.74) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL354296 | 1.00 | CYP3A4 (0.74) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL8816427 | 0.97 | CYP3A4 (0.81) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL8853802 | 0.93 | CYP3A4 (0.79) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL8853605 | 0.89 | CYP3A4 (0.82) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL11694464 | 0.89 | PGR (0.62) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL11694468 | 0.89 | PGR (0.62) | CYP3A4ABCB11PGRCYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3852608-A1 | COMPOSITIONS AND METHODS FOR GLAUCOMA | Aufbau Medical Innovations Limited (IE) | 2021-07-28 | — | — | EP | claimed |
| WO-2020061550-A1 | COMPOSITIONS AND METHODS FOR GLAUCOMA | AUFBAU MEDICAL INNOVATIONS LIMITED (IE) | 2020-03-26 | — | — | WO | claimed |
| US-20160089381-A1 | STABILITY OF PROGESTOGEN FORMULATIONS | NOVO NORDISK HEALTHCARE AG (CH) | 2016-03-31 | — | — | US | claimed |
| US-8828981-B2 | Progesterone for the treatment or prevention of spontaneous preterm birth | ALLERGAN SALES, LLC | 2014-09-09 | — | — | US | claimed |
| EP-2409690-A2 | Improved stability of progestogen formulations | Novo Nordisk Femcare AG (CH) | 2012-01-25 | — | — | EP | claimed |
| US-7884093-B2 | Progesterone for the treatment or prevention of spontaneous preterm birth | ALLERGAN SALES, LLC | 2011-02-08 | — | — | US | claimed |
| EP-2117554-A2 | PROGESTERONE FOR THE PREVENTION OF PRETERM BIRTH | Columbia Laboratories (Bermuda) Limited (BM) | 2009-11-18 | — | — | EP | claimed |
| US-20090264395-A1 | PROGESTERONE FOR THE TREATMENT OR PREVENTION OF SPONTANEOUS PRETERM BIRTH | COLUMBIA LABORATORIES, INC. | 2009-10-22 | — | — | US | claimed |
| WO-2008096122-A2 | PROGESTERONE FOR THE PREVENTION OF PRETERM BIRTH | COLUMBIA LABORATORIES (BERMUDA) LIMITED (BM) | 2008-08-14 | — | — | WO | claimed |
| US-20080188829-A1 | PROGESTERONE FOR THE TREATMENT OR PREVENTION OF SPONTANEOUS PRETERM BIRTH | ALLERGAN SALES, LLC | 2008-08-07 | — | — | US | claimed |
| US-20060257472-A1 | Stability of progestogen formulations | NOVO NORDISK FEMCARE AG (CH) | 2006-11-16 | — | — | US | claimed |
| EP-1673071-A1 | IMPROVED STABILITY OF PROGESTOGEN FORMULATIONS | Novo Nordisk Femcare AG (CH) | 2006-06-28 | — | — | EP | claimed |
| US-6977250-B2 | Prevention of ovarian cancer by administration of progestin products | NEW LIFE PHARMACEUTICALS INC. (US) | 2005-12-20 | — | — | US | claimed |
| WO-2005030176-A1 | IMPROVED STABILITY OF PROGESTOGEN FORMULATIONS | NOVO NORDISK FEMCARE AG (CH) | 2005-04-07 | — | — | WO | claimed |
| US-20020110523-A1 | Methods for screening or monitoring the risk of cardiovascular disease relating to sex steroid compound or composition intake and methods for screening sex steroid compound | KLUFT CORNELIS (NL) | 2002-08-15 | — | — | US | claimed |
| EP-0931263-A1 | METHOD OF SCREENING FOR SIDE EFFECTS OF ANTICONCEPTIVES OR ESTROGEN AND/OR PROGESTERONE REPLACEMENTS OR SUPPLEMENTS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1999-07-28 | — | — | EP | claimed |
| US-RE36247-E | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens | WOCO INVESTMENTS, LTD. (CA) | 1999-07-06 | — | — | US | claimed |
| WO-1998010293-A1 | METHOD OF SCREENING FOR SIDE EFFECTS OF ANTICONCEPTIVES OR ESTROGEN AND/OR PROGESTERONE REPLACEMENTS OR SUPPLEMENTS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1998-03-12 | — | — | WO | claimed |
| EP-0136011-B1 | A method of hormonal treatment of peri-menopausal, menopausal and post-menopausal disorders and multi-preparation pack therefor | PRE JAY HOLDINGS LTD (CA) | 1997-01-22 | — | — | EP | claimed |
| US-4826831-A | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens | PRE JAY HOLDINGS LIMITED (CA) | 1989-05-02 | — | — | US | claimed |