Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8814777 | 0.92 | TGFBR1 (0.44) | TGFBR1MAPK14KDM4EALDH1A1ADORA2A | |
| SCHEMBL8819405 | 0.90 | TGFBR1 (0.47) | TGFBR1MAPK14ADORA2AMEN1KMT2A | |
| SCHEMBL8818425 | 0.90 | TGFBR1 (0.46) | TGFBR1MAPK14KDM4EALDH1A1 | |
| SCHEMBL8816897 | 0.90 | TGFBR1 (0.46) | TGFBR1MAPK14KDM4EALDH1A1ADORA2A | |
| SCHEMBL8816866 | 0.89 | TGFBR1 (0.46) | TGFBR1MAPK14KDM4EALDH1A1ADORA2A | |
| SCHEMBL8818153 | 0.88 | TGFBR1 (0.46) | TGFBR1MAPK14KDM4EALDH1A1ADORA2A | |
| SCHEMBL8817507 | 0.87 | TGFBR1 (0.46) | TGFBR1MAPK14KDM4EALDH1A1MEN1 | |
| SCHEMBL8816999 | 0.85 | ABCG2 (0.47) | TGFBR1MAPK14KDM4EALDH1A1ADORA2A | |
| SCHEMBL8816177 | 0.84 | NR1I3 (0.51) | TGFBR1MAPK14KDM4E | |
| SCHEMBL8815695 | 0.84 | ADORA2A (0.58) | TGFBR1MAPK14ADORA2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066122-A1 | 2 - (PYRIDIN- 2 -YL) -QUINAZOLINE DERIVATIVES AND THEIR USE AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-24 | — | — | WO | disclosed |