Bromide

Bromide

SCHEMBL8816635

Br.c1ccc(CC(CC2CCCNC2)c2ccccc2)cc1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 2/20 0.38
SLC6A4 known ✓ P31645 2/20 0.38
CYP19A1 P11511 4/20 0.45
KMT2A Q03164 1/20 0.43
EED O75530 3/20 0.41
CHRNB2 P17787 3/20 0.40
CHRNA4 P43681 3/20 0.40
CPN1 P15169 1/20 0.40
CPB2 Q96IY4 1/20 0.40
CHRNB4 P30926 2/20 0.38
CHRNA3 P32297 2/20 0.38
GBA1 P04062 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL8813192 0.77 EED (0.47) KMT2AEEDCHRNB2CHRNA4CPN1
SCHEMBL1761058 0.74 EED (0.61) KMT2AEEDCHRNB2CHRNA4SLC6A2
SCHEMBL8547993 0.74 EED (0.61) KMT2AEEDCHRNB2CHRNA4SLC6A2
SCHEMBL3473180 0.74 EED (0.61) KMT2AEEDCHRNB2CHRNA4SLC6A2
Hydrochloric Acid SCHEMBL3914926 0.72 EED (0.60) KMT2AEEDCHRNB2CHRNA4SLC6A2
SCHEMBL6508972 0.71 KMT2A (0.51) KMT2ACHRNB2CHRNA4CPN1CPB2
Hydrochloric Acid SCHEMBL7068731 0.71 EED (0.58) KMT2AEEDCHRNB2CHRNA4CHRNB4
SCHEMBL3443417 0.71 KMT2A (0.57) KMT2AEEDCHRNB2CHRNA4SLC6A2
SCHEMBL3443170 0.71 KMT2A (0.57) KMT2AEEDCHRNB2CHRNA4SLC6A2
SCHEMBL3443727 0.71 KMT2A (0.57) KMT2AEEDCHRNB2CHRNA4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997023458-A1 SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed