Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL881368 | 0.94 | MAPT (0.35) | ALDH1A1POLBTDP1HTTMAPT | |
| SCHEMBL12398065 | 0.94 | MAPT (0.35) | ALDH1A1POLBTDP1HTTMAPT | |
| SCHEMBL10186058 | 0.94 | MAPT (0.35) | ALDH1A1POLBTDP1HTTMAPT | |
| SCHEMBL10148643 | 0.85 | P2RY11 (0.37) | ALDH1A1POLBHTTMAPTKDM4E | |
| SCHEMBL10149715 | 0.85 | P2RY11 (0.37) | ALDH1A1POLBHTTMAPTKDM4E | |
| SCHEMBL12243138 | 0.82 | ALDH1A1 (0.33) | ALDH1A1POLBTDP1HTTMAPT | |
| SCHEMBL12243221 | 0.82 | MAPT (0.33) | ALDH1A1POLBTDP1HTTMAPT | |
| SCHEMBL15084427 | 0.82 | ALDH1A1 (0.34) | ALDH1A1POLBTDP1HTTLMNA | |
| SCHEMBL23278055 | 0.80 | PDE2A (0.32) | — | |
| SCHEMBL882455 | 0.79 | MAPT (0.39) | ALDH1A1POLBTDP1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039787-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |