Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818120 | 0.89 | CHEK1 (0.45) | CHEK1PIM1IDO1LTKLIMK1 | |
| Diethylamine SCHEMBL8818049 | 0.89 | CHEK1 (0.47) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8816079 | 0.87 | CHEK1 (0.46) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8816075 | 0.87 | CHEK1 (0.46) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8816534 | 0.83 | CHEK1 (0.44) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8816528 | 0.83 | CHEK1 (0.44) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8818181 | 0.81 | IDO1 (0.59) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8818171 | 0.81 | IDO1 (0.59) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8818039 | 0.78 | CHEK1 (0.50) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL8817997 | 0.77 | CHEK1 (0.47) | CHEK1PIM1IDO1LTKLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997016194-A1 | NAPHTHYLAZO INHIBITION OF AMYLOIDOSIS | WARNER-LAMBERT COMPANY (US) | 1997-05-09 | — | — | WO | claimed |