Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 10/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.61 |
| ▸ | SCN1A | P35498 | 2/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.61 |
| ▸ | GBA1 | P04062 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mexiletine SCHEMBL8819167 | 0.81 | SCN4A (0.80) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| Mexiletine SCHEMBL6518643 | 0.81 | SCN4A (0.80) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| SCHEMBL21834931 | 0.80 | SCN4A (0.57) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| Mexiletine SCHEMBL9953806 | 0.80 | SCN4A (0.71) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| Mexiletine SCHEMBL2719005 | 0.79 | SCN4A (0.75) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| Mexiletine SCHEMBL2721177 | 0.79 | SCN4A (0.69) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| Mexiletine SCHEMBL2718712 | 0.79 | SCN4A (0.69) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| SCHEMBL2560624 | 0.78 | SRC (0.44) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| Mexiletine SCHEMBL9955253 | 0.76 | SCN4A (0.71) | SCN4ACYP2D6LMNASCN5ASCN1A | |
| SCHEMBL7701146 | 0.76 | SCN4A (0.66) | SCN4ACYP2D6LMNASCN5ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997027169-A1 | (2-DIMETHYLPHENOXY-1-METHYLETHYL) ETHYLAMINE | F.HOFFMANN-LA ROCHE AG (CH) | 1997-07-31 | — | — | WO | disclosed |