Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8816582 | 0.83 | ADORA2A (0.58) | TGFBR1MAPK14MAPTNPSR1ALDH1A1 | |
| SCHEMBL8818694 | 0.80 | ADORA2A (0.48) | TGFBR1MAPK14MAPTNPSR1ALDH1A1 | |
| SCHEMBL8818444 | 0.80 | ADORA2A (0.56) | TGFBR1MAPK14MAPTALDH1A1LMNA | |
| SCHEMBL8815685 | 0.80 | TGFBR1 (0.51) | TGFBR1MAPK14ALDH1A1 | |
| SCHEMBL8818479 | 0.79 | ADORA2A (0.47) | TGFBR1MAPK14MAPTNPSR1ALDH1A1 | |
| SCHEMBL8818575 | 0.78 | ADORA2A (0.43) | TGFBR1MAPK14ALDH1A1 | |
| SCHEMBL22939929 | 0.78 | CCR1 (0.48) | TGFBR1L3MBTL1ELANE | |
| SCHEMBL8818439 | 0.78 | TGFBR1 (0.49) | TGFBR1MAPK14MAPTL3MBTL1ABCB1 | |
| SCHEMBL8815690 | 0.78 | TGFBR1 (0.49) | TGFBR1MAPK14ALDH1A1 | |
| SCHEMBL8818447 | 0.78 | ADORA2A (0.54) | TGFBR1MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066122-A1 | 2 - (PYRIDIN- 2 -YL) -QUINAZOLINE DERIVATIVES AND THEIR USE AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-24 | — | — | WO | disclosed |