Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.36 |
| ▸ | EGFR | P00533 | 7/20 | 0.36 |
| ▸ | ABL1 | P00519 | 6/20 | 0.36 |
| ▸ | ABL2 | P42684 | 6/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | NPM1 | P06748 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8819661 | 0.97 | SRC (0.38) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819502 | 0.87 | PI4KA (0.47) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8820698 | 0.87 | LIMK1 (0.37) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819671 | 0.87 | EGFR (0.42) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819716 | 0.85 | PI4KA (0.48) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8820521 | 0.84 | PI4KA (0.46) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819667 | 0.83 | SRC (0.35) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819676 | 0.82 | PI4KA (0.47) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819665 | 0.80 | SRC (0.53) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819471 | 0.77 | PI4KA (0.46) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049706-A1 | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF | NOVARTIS AG (CH) | 1997-12-31 | — | — | WO | claimed |
| WO-1997049706-A1 | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF | NOVARTIS AG (CH) | 1997-12-31 | — | — | WO | disclosed |