Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 8/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ATIC | P31939 | 3/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524340 | 0.89 | GART (0.62) | GARTATICDHFR | |
| SCHEMBL9523254 | 0.89 | GART (0.62) | GARTATICDHFR | |
| Lometrexol SCHEMBL9045915 | 0.89 | GART (0.75) | GARTATICDHFR | |
| Lometrexol SCHEMBL12022771 | 0.89 | GART (0.75) | GARTATICDHFR | |
| SCHEMBL7487513 | 0.88 | GART (0.71) | GARTATICDHFR | |
| SCHEMBL8820727 | 0.86 | GART (0.52) | GARTKDM4EHPGDATICDHFR | |
| SCHEMBL8820737 | 0.86 | GART (0.52) | GARTKDM4EHPGDATICDHFR | |
| SCHEMBL7488545 | 0.86 | GART (0.71) | GARTATICDHFR | |
| SCHEMBL9524099 | 0.86 | GART (0.58) | GARTATICDHFR | |
| SCHEMBL9524506 | 0.86 | GART (0.60) | GARTATICDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049705-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-12-31 | — | — | WO | claimed |
| WO-1997049705-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-12-31 | — | — | WO | disclosed |
| WO-1997049705-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-12-31 | — | — | WO | disclosed |