Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATIC | P31939 | 3/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820727 | 1.00 | GART (0.52) | GARTKDM4EHPGDATICDHFR | |
| SCHEMBL8819374 | 0.88 | GART (0.39) | GARTKDM4EHPGDATICDHFR | |
| SCHEMBL8819377 | 0.88 | GART (0.39) | GARTKDM4EHPGDATICDHFR | |
| SCHEMBL8819683 | 0.86 | GART (0.60) | GARTKDM4EHPGDATICDHFR | |
| SCHEMBL7497224 | 0.83 | GART (0.46) | GARTATICDHFR | |
| SCHEMBL7497210 | 0.83 | GART (0.46) | GARTATICDHFR | |
| SCHEMBL9216949 | 0.82 | GART (0.45) | GARTATIC | |
| SCHEMBL9216933 | 0.82 | GART (0.45) | GARTATIC | |
| SCHEMBL9382790 | 0.82 | DHFR (0.52) | GARTATICDHFR | |
| SCHEMBL9382796 | 0.82 | DHFR (0.52) | GARTATICDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049705-A1 | 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-12-31 | — | — | WO | disclosed |