Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.32 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584370 | 0.81 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 | |
| SCHEMBL19756730 | 0.79 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 | |
| SCHEMBL22506964 | 0.73 | HTR2C (0.35) | SLC6A2SLC6A3 | |
| SCHEMBL19756637 | 0.72 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 | |
| SCHEMBL4839995 | 0.72 | AHR (0.39) | SLC6A2SLC6A4SLC6A3CHRNA7HTR3A | |
| SCHEMBL20010880 | 0.71 | ESR2 (0.46) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 | |
| SCHEMBL7138051 | 0.70 | MAPT (0.42) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL5584353 | 0.69 | KDM1A (0.41) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 | |
| SCHEMBL22721036 | 0.69 | SLC6A4 (0.38) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 | |
| Hydrochloric Acid SCHEMBL22721105 | 0.68 | SLC6A4 (0.37) | SLC6A2SLC6A4SLC6A3CYP17A1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1996022290-A1 | COMPOUNDS HAVING EFFECTS ON SEROTONIN-RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |