Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.48 |
| ▸ | ABL2 | P42684 | 5/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | CSK | P41240 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8819665 | 0.85 | SRC (0.53) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8819623 | 0.83 | SRC (0.61) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL8819507 | 0.80 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL8819502 | 0.80 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL8820521 | 0.79 | PI4KA (0.46) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL8820858 | 0.79 | SRC (0.54) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL8820875 | 0.78 | PI4KA (0.46) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL8819907 | 0.76 | SRC (0.61) | PI4KAPI4K2BPI4K2API4KBSRC | |
| SCHEMBL8820819 | 0.75 | PI4KA (0.50) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| SCHEMBL8820532 | 0.74 | SRC (0.50) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049706-A1 | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF | NOVARTIS AG (CH) | 1997-12-31 | — | — | WO | claimed |
| WO-1997049706-A1 | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF | NOVARTIS AG (CH) | 1997-12-31 | — | — | WO | disclosed |