Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | PI4KA | P42356 | 2/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820010 | 0.82 | EGFR (0.43) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL8819553 | 0.79 | RET (0.40) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL8819799 | 0.77 | RET (0.39) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL8819702 | 0.77 | EGFR (0.41) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL8820840 | 0.77 | EGFR (0.39) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL8819946 | 0.76 | BTK (0.43) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL8820874 | 0.76 | EGFR (0.38) | EGFRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5250649 | 0.73 | TNK2 (0.47) | EGFRSRCKDRALDH1A1LMNA | |
| SCHEMBL23847508 | 0.72 | TNK2 (0.48) | EGFRSRCKDRALDH1A1LMNA | |
| SCHEMBL23834462 | 0.72 | BTK (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049706-A1 | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF | NOVARTIS AG (CH) | 1997-12-31 | — | — | WO | claimed |