SCHEMBL8821041

SCHEMBL8821041

COc1ccc2[nH]c3c(C)ccc(C)c3c2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.59
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
KDM4E B2RXH2 4/20 0.59
ALDH1A1 P00352 4/20 0.59
HSD17B10 Q99714 2/20 0.59
GFER P55789 2/20 0.59
TSHR P16473 1/20 0.59
STING1 Q86WV6 1/20 0.58
PDGFRB P09619 1/20 0.57
DYRK1A Q13627 2/20 0.56
LMNA P02545 1/20 0.54
RECQL P46063 2/20 0.53
POLB P06746 2/20 0.53
TLR3 O15455 1/20 0.53
NR3C1 P04150 1/20 0.53
KIT P10721 1/20 0.53
PKM P14618 1/20 0.53
RAB9A P51151 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30143971 1.00 MAPT (0.59) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL10547752 0.79 DYRK1A (0.59) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL15202003 0.79 MAPT (0.61) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL31232723 0.79 MAPT (0.63) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL10547492 0.78 KDM4E (0.56) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL8821059 0.78 MAPT (0.51) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL8821061 0.77 GABRA1 (0.48) MAPTMEN1KMT2ASTING1PDGFRB
SCHEMBL30037086 0.76 KDM4E (0.56) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL15201803 0.76 KMT2A (0.49) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL15201968 0.76 MAPT (0.58) MAPTMEN1KMT2AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0009445-B1 PROCESS FOR THE PREPARATION OF 9-HYDROXY-ELLIPTICINE AND DERIVATIVES THEREOF ANVAR Agence Nationale de Valorisation de la Recherche (FR) 1983-05-18 EP claimed
JP-2279671-A None JP disclosed
WO-2013121385-A1 USE OF CARBAZOLE-PHENONE DERIVATIVES FOR TREATING CANCER CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2013-08-22 WO disclosed
WO-1997046559-A1 PROCESS FOR PREPARING 9-HYDROXYELLIPTICINE TANABE SEIYAKU CO., LTD. (JP) 1997-12-11 WO disclosed
JP-H02279671-A PRODUCTION OF 1,4-DIMETHYLCARBAZOLE DERIVATIVE SHIRATORI SEIYAKU KK 1990-11-15 JP disclosed
US-4483989-A BENZOYLATION 6-HYDROXYCARBAZOLE, FORMYLATING, CYCLIZATION, AND SAPONIFICATION AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) 1984-11-20 US disclosed
US-4310667-A TREATMENT OF LEUKEMIA AND SOLID TUMORS AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) 1982-01-12 US disclosed