SCHEMBL8824399

SCHEMBL8824399

Cc1nc(-c2cc(C)c(OCCCc3ccco3)c(C)c2)no1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
L3MBTL1 Q9Y468 2/20 0.43
TSHR P16473 4/20 0.41
GAA P10253 2/20 0.39
ALDH1A1 P00352 3/20 0.39
HPGD P15428 2/20 0.39
MAPT P10636 4/20 0.38
TDP1 Q9NUW8 2/20 0.36
MAPK1 P28482 1/20 0.36
MEN1 O00255 1/20 0.36
USP2 O75604 1/20 0.36
KMT2A Q03164 1/20 0.36
HAVCR2 Q8TDQ0 1/20 0.36
LMNA P02545 1/20 0.35
MITF O75030 1/20 0.35
TNF P01375 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NOD2 Q9HC29 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8824422 0.82 NR1I2 (0.53) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL9200266 0.82 NR1I2 (0.73) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL9205929 0.79 NR1I2 (0.57) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL8824446 0.79 CYP3A4 (0.49) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL8824522 0.79 NR1I2 (0.52) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL8666649 0.79 CYP3A4 (0.46) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL9179931 0.78 NR1I2 (0.65) NR1I2CYP3A4CYP2D6L3MBTL1TSHR
SCHEMBL9203587 0.78 NR1I2 (0.56) NR1I2CYP3A4CYP2D6L3MBTL1TDP1
SCHEMBL9521412 0.78 NR1I2 (0.68) NR1I2CYP3A4CYP2D6L3MBTL1TDP1
SCHEMBL9202945 0.78 NR1I2 (0.67) NR1I2CYP3A4CYP2D6L3MBTL1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5665763-A ANTIPICORNAVIRAL AGENTS SANOFI, S.A. (FR) 1997-09-09 US disclosed
US-5567717-A COMBATTING PICORNAVIRUSES STERLING WINTHROP, INC. (US) 1996-10-22 US disclosed
US-5514679-A TREATMENT OF PICORNAVIRUS INFECTIONS STERLING WINTHROP INC. (US) 1996-05-07 US disclosed
WO-1995031439-A1 THERAPEUTIC PHENOXYALKYLPYRIDAZINES AND INTERMEDIATES THEREFOR SANOFI WINTHROP, INC. (US) 1995-11-23 WO disclosed