Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825357 | 1.00 | LTB4R (0.50) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825342 | 0.90 | LTB4R (0.63) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825332 | 0.90 | LTB4R (0.63) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825251 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825256 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825397 | 0.86 | LTB4R (0.52) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825401 | 0.86 | LTB4R (0.52) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825391 | 0.85 | LTB4R (0.52) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825393 | 0.85 | LTB4R (0.52) | LTB4RLTB4R2DRD3PPARGPPARA | |
| SCHEMBL8825339 | 0.83 | LTB4R (0.63) | LTB4RLTB4R2DRD3PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |