Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825785 | 0.91 | PDGFRB (0.58) | PDGFRBMAPTACHEBACE1ALDH1A1 | |
| SCHEMBL2920292 | 0.89 | PDGFRB (0.59) | PDGFRBMAPTACHEBACE1ALDH1A1 | |
| SCHEMBL8825827 | 0.86 | PDGFRB (0.68) | PDGFRBMAPTACHEBACE1ALDH1A1 | |
| SCHEMBL9224976 | 0.83 | PDGFRB (0.64) | PDGFRBMAPTACHEBACE1MEN1 | |
| SCHEMBL8825610 | 0.82 | PDGFRB (0.61) | PDGFRBMAPTACHEBACE1ALDH1A1 | |
| SCHEMBL2917680 | 0.82 | PDGFRB (0.64) | PDGFRBMAPTACHEBACE1ALDH1A1 | |
| SCHEMBL7518944 | 0.80 | MAPT (0.54) | PDGFRBMAPTALDH1A1MAPK1HTT | |
| SCHEMBL8825617 | 0.80 | PIK3CA (0.59) | PDGFRBMAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7522631 | 0.79 | MAPT (0.55) | PDGFRBMAPTALDH1A1MAPK1HTT | |
| SCHEMBL7530560 | 0.79 | EGFR (0.48) | PDGFRBMAPTACHEBACE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661147-A | CYCLIC GUANOSINE MONOPHOSPHATE-SPECIFIC PHOSPHODIESTERASE INHIBITOR; TREATING CARDIOVASCULAR DISORDER | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0668280-A1 | IMIDAZOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |