Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825735 | 0.94 | EGFR (0.60) | EGFRLMNAHTTKDM4EHPGD | |
| SCHEMBL8825839 | 0.90 | EGFR (0.62) | EGFRLMNAHTTKDM4EHPGD | |
| SCHEMBL8825695 | 0.90 | EGFR (0.67) | EGFRLMNAHTTKDM4EHPGD | |
| SCHEMBL7520287 | 0.87 | EGFR (0.50) | EGFRLMNAHTTHPGDSMN1; SMN2 | |
| SCHEMBL8825793 | 0.86 | EGFR (0.64) | EGFRLMNAHTTKDM4EHPGD | |
| SCHEMBL8795337 | 0.86 | EGFR (0.46) | EGFRHTTKDM4E | |
| SCHEMBL7531564 | 0.85 | EGFR (0.57) | EGFRLMNAHTTKDM4EHPGD | |
| SCHEMBL8825780 | 0.84 | EGFR (0.60) | EGFRLMNAHTTKDM4EHPGD | |
| SCHEMBL8796704 | 0.83 | EGFR (0.50) | EGFRHTTKDM4EHPGD | |
| SCHEMBL8795238 | 0.82 | EGFR (0.47) | EGFRHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661147-A | CYCLIC GUANOSINE MONOPHOSPHATE-SPECIFIC PHOSPHODIESTERASE INHIBITOR; TREATING CARDIOVASCULAR DISORDER | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0668280-A1 | IMIDAZOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |