Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | USP10 | Q14694 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | USP13 | Q92995 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795337 | 0.94 | EGFR (0.46) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL7522588 | 0.91 | EGFR (0.47) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL8825884 | 0.89 | ALDH1A1 (0.55) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL7524564 | 0.89 | EGFR (0.50) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL8825977 | 0.88 | MAPK1 (0.55) | EGFRERBB2HTTMAPK1 | |
| SCHEMBL8825554 | 0.88 | EGFR (0.57) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL8795709 | 0.88 | EGFR (0.49) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL8825839 | 0.88 | EGFR (0.62) | EGFRKDM4EHTTMAPK1 | |
| SCHEMBL7521999 | 0.87 | EGFR (0.50) | EGFRERBB2KDM4EALDH1A1HTT | |
| SCHEMBL8825848 | 0.87 | EGFR (0.50) | EGFRERBB2KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |