Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825970 | 1.00 | ALDH1A1 (0.56) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL11178698 | 0.84 | ALDH1A1 (0.58) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL3312540 | 0.82 | ALDH1A1 (0.62) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL27878990 | 0.82 | ALDH1A1 (0.62) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL23009741 | 0.80 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL21424973 | 0.80 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL20738614 | 0.80 | ALDH1A1 (0.60) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL21425067 | 0.80 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL20738480 | 0.80 | ALDH1A1 (0.60) | ALDH1A1LMNAHPGDHIF1AHSD11B1 | |
| SCHEMBL21138878 | 0.80 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDHIF1AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |