Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8494497 | 1.00 | ALOX5 (0.61) | ALOX5PTGS1PTGS2L3MBTL1LTB4R | |
| SCHEMBL8826002 | 1.00 | ALOX5 (0.61) | ALOX5PTGS1PTGS2L3MBTL1LTB4R | |
| SCHEMBL8494501 | 1.00 | ALOX5 (0.61) | ALOX5PTGS1PTGS2L3MBTL1LTB4R | |
| SCHEMBL8694100 | 0.86 | ALOX5 (0.51) | ALOX5PTGS1PTGS2L3MBTL1LTB4R | |
| SCHEMBL8498369 | 0.85 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8826226 | 0.85 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8826219 | 0.85 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8498367 | 0.85 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6418344 | 0.82 | ALOX5 (0.74) | ALOX5PTGS1PTGS2L3MBTL1LTB4R | |
| SCHEMBL8652025 | 0.80 | ALOX5 (0.76) | ALOX5PTGS1PTGS2L3MBTL1LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |