Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497848 | 1.00 | ALOX5 (0.53) | ALOX5PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL8497846 | 1.00 | ALOX5 (0.53) | ALOX5PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL8826036 | 1.00 | ALOX5 (0.53) | ALOX5PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL8493801 | 0.88 | LPAR1 (0.51) | — | |
| SCHEMBL4959388 | 0.88 | LPAR1 (0.51) | — | |
| SCHEMBL8825946 | 0.88 | LPAR1 (0.51) | — | |
| SCHEMBL8493183 | 0.88 | LPAR1 (0.51) | — | |
| SCHEMBL9255423 | 0.88 | LPAR1 (0.51) | — | |
| SCHEMBL8493909 | 0.88 | LPAR1 (0.51) | — | |
| SCHEMBL8825925 | 0.88 | LPAR1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | claimed |
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |