Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 16/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.56 |
| ▸ | CDK1 | P06493 | 12/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266040 | 0.94 | CDK2 (0.64) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL4402025 | 0.93 | CDK2 (0.64) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL29385503 | 0.93 | CDK2 (0.64) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL6267556 | 0.86 | CDK2 (0.67) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL8826284 | 0.80 | CDK2 (0.51) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL30583141 | 0.79 | IRAK4 (0.41) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL4556489 | 0.79 | IRAK4 (0.41) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL7984872 | 0.79 | CDK2 (0.42) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL8618497 | 0.78 | CDK1 (0.44) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL21484455 | 0.77 | CDK2 (0.36) | CDK2CCNA2CCNA1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663154-A | VIRICIDES, HIV, HEPATITIS | GLAXO WELLCOME INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0648218-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-19 | — | — | EP | disclosed |
| EP-0625158-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |
| WO-1994001443-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-01-20 | — | — | WO | disclosed |
| WO-1993014103-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-22 | — | — | WO | disclosed |