Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | FABP3 | P05413 | 2/20 | 0.37 |
| ▸ | FABP7 | O15540 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8496545 | 1.00 | GPR88 (0.39) | GPR88KDM4EPKMNPSR1SMN1; SMN2 | |
| SCHEMBL8696052 | 0.84 | GPR88 (0.42) | GPR88NPSR1SMN1; SMN2EDNRBEDNRA | |
| SCHEMBL31393802 | 0.81 | SMN1; SMN2 (0.41) | GPR88KDM4EPKMNPSR1SMN1; SMN2 | |
| SCHEMBL8825958 | 0.80 | TACR1 (0.47) | GPR88KDM4ESMN1; SMN2EDNRBEDNRA | |
| SCHEMBL24359328 | 0.71 | KMT2A (0.41) | KDM4ENPSR1SMN1; SMN2MEN1KMT2A | |
| Biphenyl SCHEMBL5496359 | 0.69 | KMT2A (0.41) | GPR88PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20152515 | 0.68 | CDC25B (0.40) | KDM4ENPSR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10787360 | 0.68 | KMT2A (0.40) | GPR88NPSR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7450697 | 0.67 | TACR1 (0.49) | GPR88KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL8693959 | 0.67 | TACR1 (0.43) | GPR88KDM4ENPSR1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |