Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 13/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.62 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882806 | 0.83 | F2R (1.00) | F2RL3MBTL1ALDH1A1 | |
| SCHEMBL882721 | 0.83 | F2R (1.00) | F2RALDH1A1 | |
| SCHEMBL16101177 | 0.82 | L3MBTL1 (0.74) | L3MBTL1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL29766853 | 0.82 | F2R (1.00) | F2R | |
| SCHEMBL882467 | 0.82 | F2R (1.00) | F2R | |
| SCHEMBL882797 | 0.82 | F2R (1.00) | F2RHTTALDH1A1 | |
| SCHEMBL882809 | 0.82 | F2R (1.00) | F2RKDM4E | |
| SCHEMBL10069466 | 0.81 | F2R (0.82) | F2RL3MBTL1HTTALDH1A1 | |
| SCHEMBL12383061 | 0.81 | F2R (0.77) | F2RALDH1A1KDM4EGAA | |
| SCHEMBL882778 | 0.81 | F2R (1.00) | F2RL3MBTL1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |