Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.75 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | F2R | P25116 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | SMO | Q99835 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259704 | 0.86 | KCNK3 (0.82) | KCNK3KCNK9SMN1; SMN2F2RKMT2A | |
| SCHEMBL19491387 | 0.86 | KCNK3 (0.78) | KCNK3KCNK9SMN1; SMN2F2RMAPK1 | |
| SCHEMBL15778718 | 0.85 | FADS1 (0.74) | KCNK3KCNK9SMN1; SMN2F2RKMT2A | |
| SCHEMBL8278422 | 0.84 | MAPT (0.63) | KCNK3KCNK9SMN1; SMN2F2RMAPK1 | |
| SCHEMBL882797 | 0.83 | F2R (1.00) | KCNK3KCNK9SMN1; SMN2F2RALDH1A1 | |
| SCHEMBL15177176 | 0.83 | KCNK3 (1.00) | KCNK3KCNK9KMT2AMEN1MAPT | |
| SCHEMBL1203522 | 0.83 | SMO (0.80) | KCNK3KCNK9SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL811056 | 0.83 | KCNK3 (0.68) | KCNK3KCNK9SMN1; SMN2F2RKMT2A | |
| SCHEMBL11578739 | 0.83 | KCNK3 (0.68) | KCNK3KCNK9SMN1; SMN2F2RMAPK1 | |
| SCHEMBL5668766 | 0.83 | FADS1 (0.68) | KCNK3KCNK9SMN1; SMN2MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |