Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.64 |
| ▸ | DRD3 | P35462 | 4/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.60 |
| ▸ | HTR1A | P08908 | 7/20 | 0.59 |
| ▸ | HTR7 | P34969 | 5/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10546259 | 0.96 | DRD2 (0.63) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL10545947 | 0.92 | DRD2 (0.66) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL10676614 | 0.87 | DRD2 (0.68) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL29395171 | 0.86 | DRD2 (0.76) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL2215388 | 0.86 | DRD2 (0.76) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8828610 | 0.85 | DRD2 (0.57) | DRD2DRD3DRD4ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL29072812 | 0.84 | DRD2 (0.74) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL11047866 | 0.84 | DRD2 (0.74) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9293656 | 0.83 | DRD2 (0.66) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL10546695 | 0.83 | DRD2 (0.70) | DRD2DRD3DRD4ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |
| US-4841051-A | ALPHA-RECEPTOR BLOCKING AGENTS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1989-06-20 | — | — | US | disclosed |
| EP-0228605-A1 | Phenylpiperazine derivatives | Nippon Kayaku Kabushiki Kaisha (JP) | 1987-07-15 | — | — | EP | disclosed |
| WO-1984004302-A1 | SUBSTITUTED PICOLINIC ACIDS, PROCESSES FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-08 | — | — | WO | disclosed |
| EP-0123700-A1 | Substituted picolinic acids, processes for their preparation, their use, and pharmaceutical preparations containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-11-07 | — | — | EP | disclosed |