Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828501 | 0.74 | ADRA1D (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL8828658 | 0.72 | MAPT (0.57) | MAPT | |
| SCHEMBL14376019 | 0.70 | CYP3A4 (0.57) | LRRK2KDM4EMAPK1ALDH1A1MEN1 | |
| SCHEMBL10983478 | 0.69 | HTT (0.45) | KDM4EMAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8349172 | 0.68 | HTT (0.50) | KDM4EMAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12963701 | 0.68 | KDM4E (0.60) | KDM4EMAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL30605517 | 0.68 | KDM4E (0.56) | KDM4EMAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL20147158 | 0.68 | CYP3A4 (0.44) | KDM4EMAPK1ALDH1A1LMNAHPGD | |
| SCHEMBL13969958 | 0.68 | FERMT2 (0.46) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7841902 | 0.67 | KDM4E (0.54) | KDM4EMAPK1ALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |