SCHEMBL8828822

SCHEMBL8828822

CO[C@@H]1CN(CCCn2nc(Cl)ccc2=O)CC[C@@H]1NC(=O)c1cc(Cl)c(N)c2c1OCCC2

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR4 Q13639 12/20 0.52
KCNH2 Q12809 8/20 0.52
HTR1A P08908 2/20 0.52
ADRA2C P18825 2/20 0.52
ADRA1A P35348 2/20 0.52
HTR3A P46098 2/20 0.52
ACHE P22303 1/20 0.52
PTGS1 P23219 1/20 0.52
CYP3A4 P08684 3/20 0.45
CYP2D6 P10635 3/20 0.45
CYP2C9 P11712 2/20 0.45
USP2 O75604 1/20 0.45
HTR3E A5X5Y0 1/20 0.45
MLNR O43193 1/20 0.45
CACNA1F O60840 1/20 0.45
HTR3B O95264 1/20 0.45
HMGCR P04035 1/20 0.45
ADRA2A P08913 1/20 0.45
DRD2 P14416 1/20 0.45
ADRA2B P18089 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8828815 1.00 HTR4 (0.52) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8686062 1.00 HTR4 (0.52) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8828849 0.86 HTR4 (0.59) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8686747 0.86 HTR4 (0.59) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8828857 0.86 HTR4 (0.59) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8869182 0.85 HTR4 (0.43) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8684723 0.83 HTR4 (0.56) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8684733 0.83 HTR4 (0.56) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8684718 0.83 HTR4 (0.56) HTR4KCNH2HTR1AADRA2CADRA1A
SCHEMBL8828810 0.83 HTR4 (0.60) HTR4KCNH2HTR1AADRA2CADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616583-A GASTROINTESTINAL MOTILITY JANSSEN PHARMACEUTICA N.V. (BE) 1997-04-01 US disclosed
US-5610157-A N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1997-03-11 US disclosed
US-5602129-A GASTROINTESTINAL DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1997-02-11 US disclosed
US-5576448-A GASTROINTESTINAL DISORDERS, ANTIEMETICS, ANTIPSYCHOTICS OR NEUROLEPTIC AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 1996-11-19 US disclosed
US-5565582-A GASTROINTESTINAL DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1996-10-15 US disclosed
US-5554772-A CHEMICAL INTERMEDIATES; GASTROINTESTINAL DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-10 US disclosed
US-5552553-A CHEMICAL INTERMEDIATES FOR LAXATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-03 US disclosed
US-5536733-A GASTROINTESTINAL JANSSEN PHARMACEUTICA N.V. (BE) 1996-07-16 US disclosed
US-5521314-A CHEMICAL INTERMEDIATES FOR CENTRAL NERVOUS SYSTEM, ANTIEMETICS, ANTIPSYCHOTIC AGENTS OR NEUROLEPTIC AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 1996-05-28 US disclosed
US-5374637-A Stimulate gastrointestinal motility JANSSEN PHARMACEUTICA N.V. (BE) 1994-12-20 US disclosed
EP-0389037-A1 N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1990-09-26 EP disclosed