SCHEMBL8829183

SCHEMBL8829183

O=C(O)CN(CCC(O)(Cn1cncn1)C(F)F)C(=O)c1ccc(OCC(F)(F)C(F)F)cc1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
USP2 O75604 1/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSP90AA1 P07900 1/20 0.31
IDH1 O75874 1/20 0.31
CFTR P13569 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8554861 0.85 CYP3A4 (0.49) CYP3A4CYP2C9CYP2C19HSP90AA1
SCHEMBL8554392 0.84 CYP3A4 (0.38) HTTKMT2ASMN1; SMN2CYP3A4CYP2C9
SCHEMBL8554074 0.76 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19HSP90AA1
SCHEMBL8554860 0.74 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19HSP90AA1
SCHEMBL8554855 0.74 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19HSP90AA1
SCHEMBL8556550 0.74 HSP90AA1 (0.39) KMT2AMAPTCYP3A4CYP2C9CYP2C19
SCHEMBL8554388 0.73 CYP3A4 (0.39) HTTKMT2ASMN1; SMN2CYP3A4CYP2C9
SCHEMBL8554382 0.73 CYP3A4 (0.39) HTTKMT2ASMN1; SMN2CYP3A4CYP2C9
SCHEMBL8554163 0.71 CYP3A4 (0.54) CYP3A4CYP2C9CYP2C19HSP90AA1
SCHEMBL8553352 0.69 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5646294-A FUNGICIDES J. URIACH & CIA. S.A. (ES) 1997-07-08 US disclosed