Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.77 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.77 |
| ▸ | CLK2 | P49760 | 1/20 | 0.77 |
| ▸ | BLK | P51451 | 1/20 | 0.77 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.77 |
| ▸ | STK3 | Q13188 | 1/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.77 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.77 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.77 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27248939 | 0.94 | ROCK2 (0.74) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL27066406 | 0.91 | ROCK2 (0.70) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL23587500 | 0.90 | ROCK2 (0.69) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL10218168 | 0.88 | ROCK2 (0.71) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Belumosudil SCHEMBL878202 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Belumosudil SCHEMBL29575654 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Belumosudil SCHEMBL29361017 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Belumosudil SCHEMBL29364140 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL10221643 | 0.87 | ROCK2 (0.72) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL28777039 | 0.86 | ROCK2 (0.63) | ROCK2ROCK1CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040499-A2 | METABOLIC INHIBITORS | SURFACE LOGIX, INC. (US) | 2012-03-29 | — | — | WO | disclosed |